Akalitus tells Jackie she has to admit that she’s on drugs, or will have to take a test. Coop confronts Jackie, but she has surprising news for him.
Jackie reluctantly attends Kevin’s wedding. Carrie makes demands on Coop.
Jackie and Frank breakup. Jackie realizes the only way she can continue to use drugs is by separating herself, from those closest to her. Carrie forgets Coop’s 40th birthday. Zoey decides that she wants to be a nurse practitioner. The DEA’s investigation continues.
Jackie has to act quickly when she finds out she will have to provide a urine sample as part of a DEA investigation. Kevin and Mia begin making wedding plans. Coop and Carrie find a way of getting around their no sex in hospital rule.
Jackie detoxes at home and dreams she is back working at the hospital, where she meets a mysterious patient who exposes Jackie’s greatest fear. Meanwhile, Frank objects to Grace moving back home and Jackie makes a difficult decision concerning Frank.
Jackie is ambushed by Antoinette – who makes a harrowing confession that spurs Jackie once and for all to get sober. After white-knuckling it through the day at All Saints, however, she comes to a crossroads with the discovery of Oxy in Grace’s room. Meanwhile, Akalitus attempts to cheer up Zoey by naming her nurse
Jackie’s fake identity is compromised. Prentiss plans a date with Zoey.
Zoey confronts Prentiss. Jackie pops a surprising question to Frank.
Jackie goes off the deep end over Kevin’s fiancé. Frank discloses a secret.
Coop gets the crushing news that his sperm count is too low. Carrie gets a lucky break, which leads to a medical segment on the local news. Jackie gets blindsided when Grace – arrested for shoplifting – drops a bomb.
Jackie tries to find a new drug source but comes up empty until Frank takes her dancing and she hooks up with a dealer. Meanwhile, Coop is recruited by a so-called sperm scout and Akalitus wins a classic car in a poker game.
Jackie’s using again – and getting her drugs at the gym.
The fifth season ends with Jackie celebrating her one-year anniversary of being sober. But her joy is cut short when she fights with Frank. Later, Zoey becomes rigid around Prentiss and Jackie takes something that doesn’t belong to her.
Episode 8 – Forget It: Kevin interrupts Jackie and Frank’s night Jackie attends an AA meeting Akalitus learns the reason for her memory loss Zoey helps Prentiss organize his office Grace tells Jackie that she broke up with Danny. Episode 9 – Heart: Jackie and Frank have sex. Kevin finds a bag of pills in
Akalitus forgets to hire an escort for a psych patient who ends up laying waste to the pharmacy. Frank cancels his lunch date with Jackie because he picked up an extra shift. Zoey hears Coop and Carrie having sex. Jackie worries about Frank when news that a cop has been shot reaches the hospital.